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Citations 5. References HSV type 2 HSV-2 causes genital diseases and neonatal infections through a maternal genital tract to the newborn Pellet and Roizman, Genital herpes caused by HSV-2 is one of the most important sexually transmitted diseases Bystrick? Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells.
Full-text available. Mar Acta Virol. In addition, it is known that nectin-2 is also functional as a receptor for HSV-2, although the binding to the gD is weak. To examine an antiviral potential of a soluble form of human nectin-2 hNectin-2Ig , transfected Vero cells expressing the entire ectodomain of nectin-2 fused to the Fc portion of human IgG were established.
Competitive ELISA demonstrated that accumulation of hNectin-2Ig in transfected cells increased significantly in a cell culture time dependent manner. Viral growth of several HSV-2 strains was significantly inhibited in the transfected cells that were cultured for 72 hr compared with control Vero cells, but not in cells that were cultured for 24 hr. These results indicate that accumulation of a soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.